2751-09-9
Chemical Structure
Troleandomycin
Synonym(s): Triacetyloleandomycin
- CAS No.: 2751-09-9
- Formula:C41H67NO15
- Molecular Weight:813.97
IUPAC Name: (2S,3R,4S,6R)-2-(((3R,5R,6S,7S,8R,11R,12S,13R,14S,15S)-6-acetoxy-12-(((2R,4S,5S,6S)-5-acetoxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadecan-14-yl)oxy)-4-(dimethylamino)-6-methyltetrahydr
InChIKey: LQCLVBQBTUVCEQ-QTFUVMRISA-N
SMILES: O=C1[C@@]2(C[C@@H]([C@@H]([C@H]([C@@H]([C@@H](C)C(O[C@H](C)[C@H](C)[C@@](OC(C)=O)([H])[C@H]1C)=O)O[C@@]3([H])C[C@@H]([C@@H](OC(C)=O)[C@H](C)O3)OC)C)O[C@@]4([H])[C@@H]([C@H](C[C@@H](C)O4)N(C)C)OC(C)=O)C)CO2
Biological Activity: Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Troleandomycin | 99.30% | Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study. | ||||||||||||||||||||
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Troleandomycin (Standard) | ≥98% | Troleandomycin (Standard) (Triacetyloleandomycin (Standard)) is the analytical standard of Troleandomycin (HY-108881). This product is intended for research and analytical applications. Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study. | ||||||||||||||||||||
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References
- [1]. Shingen Misaka, et al. Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats. Drug Metab Pharmacokinet. 2013;28(6):514-8. [Content Brief]
- [2]. A Honda, et al. Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis. J Biol Chem. 2001 Sep 14;276(37):34579-85. [Content Brief]
- [3]. D J Evans, et al. Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma. Cochrane Database Syst Rev. 2001;(2):CD002987. [Content Brief]
