2754396-62-6
2754396-62-6
Chemical Structure
EGFR-IN-220
- CAS No.: 2754396-62-6
- Formula:C28H31BrN8O4S
- Molecular Weight:655.57
InChIKey: KYOHEEHGKIYDCK-UHFFFAOYSA-N
SMILES: CCC1=C(C=C(C(NC2=NC=C(C(NC3=CC=C4N=CC=NC4=C3N(S(C)(=O)=O)C)=N2)Br)=C1)OC)N5CC6(C5)COC6
Biological Activity: EGFR-IN-220 is a mutant-selective EGFR tyrosine kinase inhibitor. EGFR-IN-220 inhibits EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK, with enzymatic IC50 values <5 nM. EGFR-IN-220 exhibits antiproliferative activity in cell models expressing EGFR triple-mutant variants. EGFR-IN-220 can be used for research on non-small cell lung cancer[1].
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EGFR-IN-220 | EGFR-IN-220 is a mutant-selective EGFR tyrosine kinase inhibitor. EGFR-IN-220 inhibits EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK, with enzymatic IC50 values <5 nM. EGFR-IN-220 exhibits antiproliferative activity in cell models expressing EGFR triple-mutant variants. EGFR-IN-220 can be used for research on non-small cell lung cancer. | |||||||||||||||||||||
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