2755770-50-2
Chemical Structure
Temporin-GHd
- CAS No.: 2755770-50-2
- Formula:C76H108N18O16
- Molecular Weight:1529.78
InChIKey: YCWIQPAQDXZSCK-SUDAOBRNSA-N
SMILES: O=C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=CC=C5)N
Biological Activity: Temporin-GHd exhibits antibacterial activity against Streptococcus mutans (MIC=13.1 μM; MBC=26 μM). Temporin-GHd increases the permeability of the bacterial cell membrane, causing membrane damage and leakage of cellular contents. Temporin-GHd disrupts preformed biofilms at high concentrations. Temporin-GHd can bind to bacterial DNA, inhibiting DNA migration[1].
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Temporin-GHd | Temporin-GHd exhibits antibacterial activity against Streptococcus mutans (MIC=13.1 μM; MBC=26 μM). Temporin-GHd increases the permeability of the bacterial cell membrane, causing membrane damage and leakage of cellular contents. Temporin-GHd disrupts preformed biofilms at high concentrations. Temporin-GHd can bind to bacterial DNA, inhibiting DNA migration. | |||||||||||||||||||||
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