2755794-94-4
2755794-94-4
Chemical Structure
MD102
- CAS No.: 2755794-94-4
- Formula:C13H4BrCl2FN2O2
- Molecular Weight:389.99
InChIKey: IBGHENGSDCVIGZ-UHFFFAOYSA-N
SMILES: BrC1=CC=C(C2=NC(C(C(Cl)=C(Cl)C3=O)=O)=C3N2)C=C1F
Biological Activity: MD102 is an orally active transglutaminase 2 (TG2) inhibitor with an IC50 of 0.35 μM. MD102 binds to the β-sandwich domain of TG2, disrupts the interaction between TG2 and p53, stabilizes p53, and reduces the activity of p-AKT and p-mTOR signaling pathways. MD102 induces cell apoptosis and inhibits tumor growth. MD102 can be used for the research of renal cell carcinoma[1].
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MD102 | 98.01% | MD102 is an orally active transglutaminase 2 (TG2) inhibitor with an IC50 of 0.35 μM. MD102 binds to the β-sandwich domain of TG2, disrupts the interaction between TG2 and p53, stabilizes p53, and reduces the activity of p-AKT and p-mTOR signaling pathways. MD102 induces cell apoptosis and inhibits tumor growth. MD102 can be used for the research of renal cell carcinoma. | ||||||||||||||||||||
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