2756347-51-8
2756347-51-8
Chemical Structure
LC1343
- CAS No.: 2756347-51-8
- Formula:C22H17N3O5S3
- Molecular Weight:499.58
InChIKey: MMWQFEVTTBXVHF-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=CC=C(S(=O)(C)=O)C=C2S1)C(C3=CC=CC=C3)SC4=CC=C([N+]([O-])=O)C=C4
Biological Activity: LC1343 is a human thymidylate synthase (hTS) inhibitor with an IC50 of 7 μM. LC1343 inhibits cancer cell growth and induces apoptosis in cancer cells. LC1343 can be used for the research of ovarian cancer, colorectal cancer, and pancreatic cancer[1][2].
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LC1343 | LC1343 is a human thymidylate synthase (hTS) inhibitor with an IC50 of 7 μM. LC1343 inhibits cancer cell growth and induces apoptosis in cancer cells. LC1343 can be used for the research of ovarian cancer, colorectal cancer, and pancreatic cancer. | |||||||||||||||||||||
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References
- [1]. Gaetano Marverti, et al. Increased Ovarian and Colorectal Cancer Cell Sensitivity to Platinum Drugs and innovative TS Inhibitors by Electroporation. bioRxiv. 2026.
- [2]. Costantino L, et al. Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife. 2022;11:e73862. Published 2022 Dec 7. [Content Brief]
