2756846-09-8
Chemical Structure
Chalcones A-N-5
- CAS No.: 2756846-09-8
- Formula:C21H20N4O4
- Molecular Weight:392.41
IUPAC Name: (E)-3-(4-((2-(dimethylamino)pyrimidin-5-yl)amino)phenyl)-1-(2,3,4-trihydroxyphenyl)prop-2-en-1-one
InChIKey: DYNGZTFQOLESRC-WEVVVXLNSA-N
SMILES: CN(C1=NC=C(C=N1)NC2=CC=C(C=C2)/C=C/C(C3=C(C(O)=C(C=C3)O)O)=O)C
Biological Activity: Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD[1].
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Chalcones A-N-5 | Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD. | |||||||||||||||||||||
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