2757182-99-1
2757182-99-1
Chemical Structure
HIV-1 inhibitor-15
- CAS No.: 2757182-99-1
- Formula:C24H20N6
- Molecular Weight:392.46
IUPAC Name: 4-((4-((2,6-dimethyl-4-(pyridin-4-yl)phenyl)amino)pyrimidin-2-yl)amino)benzonitrile
InChIKey: PAYRTWYMJYKBOL-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(NC2=NC=CC(NC3=C(C)C=C(C4=CC=NC=C4)C=C3C)=N2)C=C1
Biological Activity: HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].
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HIV-1 inhibitor-15 | HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability. | |||||||||||||||||||||
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