2757682-02-1
Chemical Structure
NRERcl
- CAS No.: 2757682-02-1
- Formula:C25H26ClN3O3
- Molecular Weight:451.95
InChIKey: QEVNHFKFYXQPTK-UHFFFAOYSA-N
SMILES: CCN(C1=CC=C2N=C3C(OC2=C1)=CC(C4=C3C=CC=C4)=O)CCCC(NCCCCl)=O
Biological Activity: NRERcl is a Golgi-targeting lipid order probe. NRERcl can be used for imaging the lipid order and polarity of the endoplasmic reticulum. NRERcl carries a propyl chloride targeting group that directs it to the endoplasmic reticulum, and it functions via excited-state charge transfer, emitting colors according to local polarity changes associated with lipid order. NRERcl partitions into lipid membranes, with a higher fluorescence quantum yield in membrane environments than in aqueous buffers; its excitation wavelength is 520 nm, and the emission maximum varies with the environment (Ex/Em = 520/584-653 nm)[1][2].
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NRERcl | NRERcl is a Golgi-targeting lipid order probe. NRERcl can be used for imaging the lipid order and polarity of the endoplasmic reticulum. NRERcl carries a propyl chloride targeting group that directs it to the endoplasmic reticulum, and it functions via excited-state charge transfer, emitting colors according to local polarity changes associated with lipid order. NRERcl partitions into lipid membranes, with a higher fluorescence quantum yield in membrane environments than in aqueous buffers; its excitation wavelength is 520 nm, and the emission maximum varies with the environment (Ex/Em = 520/584-653 nm). | |||||||||||||||||||||
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References
- [1]. Danylchuk DI, et al. Targeted Solvatochromic Fluorescent Probes for Imaging Lipid Order in Organelles under Oxidative and Mechanical Stress. Journal of the American Chemical Society. 2021 Jan 20;143(2):912-924.
- [2]. Sokoya T, et al. Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. eLife. 2022 Sep 14;11:e79278. [Content Brief]
