2757991-65-2
Chemical Structure
DHFR-IN-1
- CAS No.: 2757991-65-2
- Formula:C22H22N6O4S2
- Molecular Weight:498.58
IUPAC Name: (Z)-3-(2-(4-(4-hydroxyphenyl)thiazol-2-yl)hydrazono)-5-((4-methylpiperazin-1-yl)sulfonyl)indolin-2-one
InChIKey: NEJKFZHFMGAWIY-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)S(=O)(C2=CC=C3NC(/C(C3=C2)=N\NC4=NC(C5=CC=C(C=C5)O)=CS4)=O)=O
Biological Activity: DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249[1].
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DHFR-IN-1 | DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249. | |||||||||||||||||||||
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