2758171-70-7
2758171-70-7
Chemical Structure
AAA-10
- CAS No.: 2758171-70-7
- Formula:C25H41FO5S
- Molecular Weight:472.65
IUPAC Name: (3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-6-fluoro-5-oxohexan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl hydrogen sulfate
InChIKey: MVPISWRWXKQVBV-CIQXVCGBSA-N
SMILES: C[C@H](CCC(CF)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](OS(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Biological Activity: AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AAA-10 | 99.97% | AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively. | ||||||||||||||||||||
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Glycolithocholic acid 3-sulfate (Standard) | ≥98% | Glycolithocholic acid 3-sulfate (Standard) (Glycolithocholate sulfate (Standard)) is the analytical standard of Glycolithocholic acid 3-sulfate (HY-113074). This product is intended for research and analytical applications. Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease. | ||||||||||||||||||||
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Lithocholic acid 3-sulfate disodium | 99.93% | Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn2+, and 0.88 μM and 0.97 μM in the presence of Zn2+. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases. | ||||||||||||||||||||
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Chenodeoxycholic acid 3-sulfate | Chenodeoxycholic acid 3-sulfate is a bile acid. Chenodeoxycholic acid 3-sulfate level corresponds closely with the extent of hepatic dysfunction. | |||||||||||||||||||||
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Gut restricted-7 | 99.54% | Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice. | ||||||||||||||||||||
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(3β)-Allopregnanolone sulfate sodium | 99.07% | (3β)-Allopregnanolone sulfate sodium is a Nav1.3 α-subunit inhibitor (IC50: 75 μM for Nav1.3 + β1; 26 μM for Nav1.3 + β3). (3β)-Allopregnanolone sulfate sodium is involved in the analgesic mechanism of Allopregnanolone. (3β)-Allopregnanolone sulfate (sodium) can be used in the research of neuropathic pain. | ||||||||||||||||||||
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SPP-002 | 98.0% | SPP-002 is a ST6GAL1 inhibitor with a human IC50 of 16.7 μM. SPP-002 selectively inhibits N-glycan sialylation over O-glycan sialylation and binds strongly to the enzyme active site. SPP-002 suppresses expression of signaling proteins in the integrin/FAK/paxillin pathway. SPP-002 can be used for the research of triple negative breast cancer metastasis. | ||||||||||||||||||||
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Lithocholic acid | 99.96% | Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist. | ||||||||||||||||||||
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Isoallolithocholic acid (Standard) | ≥98% | Isoallolithocholic acid (Standard) is the analytical standard of Isoallolithocholic acid. This product is intended for research and analytical applications. Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation. | ||||||||||||||||||||
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Deoxycholic acid 3-sulfate | Deoxycholic acid 3-sulfate is a sulfated metabolite of deoxycholic acid, belonging to the sulfate ester form of secondary bile acids. The proportion of Deoxycholic acid 3-sulfate in serum from both healthy states and cholestatic states is below the limit of detection. | |||||||||||||||||||||
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5β-Pregnane-3α,20α-diol 3-sulfate sodium | 99.9% | 5β-Pregnane-3α,20α-diol 3-sulfate sodium is a steroid sulfate found in human urine and plasma. | ||||||||||||||||||||
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