2758623-12-8
2758623-12-8
Chemical Structure
Trk-IN-9
- CAS No.: 2758623-12-8
- Formula:C23H24ClFN6O
- Molecular Weight:454.93
IUPAC Name: (R)-3-((5-chloro-4-((3-fluorobenzyl)amino)pyrimidin-2-yl)amino)-N-(piperidin-3-yl)benzamide
InChIKey: DUAIEVYTIKHMGW-LJQANCHMSA-N
SMILES: FC1=CC=CC(CNC2=NC(NC3=CC(C(N[C@@H]4CCCNC4)=O)=CC=C3)=NC=C2Cl)=C1
Biological Activity: Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Trk-IN-9 | 98.03% | Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers. | ||||||||||||||||||||
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