2758788-95-1
Chemical Structure
AChE-IN-6
- CAS No.: 2758788-95-1
- Formula:C29H41N5O2
- Molecular Weight:491.67
IUPAC Name: 6-(5-(dimethylamino)-2-hydroxyphenyl)-2-(6-((2-(dimethylamino)benzyl)(ethyl)amino)hexyl)pyridazin-3(2H)-one
InChIKey: LUSWYKZXSSNJEA-UHFFFAOYSA-N
SMILES: CCN(CC1=C(C=CC=C1)N(C)C)CCCCCCN2N=C(C=CC2=O)C3=CC(N(C)C)=CC=C3O
Biological Activity: AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease[1].
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AChE-IN-6 | AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease. | |||||||||||||||||||||
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