2759280-09-4
2759280-09-4
Chemical Structure
WS-11
- CAS No.: 2759280-09-4
- Formula:C26H22FN9O2
- Molecular Weight:511.51
InChIKey: IFRVYAWMDQAGGU-UHFFFAOYSA-N
SMILES: NC1=C2C(C3=CC=C(C=C3F)C(NC4=NC=CC=C4)=O)=NN(C2=NC=N1)C5CCCN(C5)C6=NC(C=C6)=O
Biological Activity: WS-11 is a non-covalent reversible BTK inhibitor with IC50s of 3.9 nM and 2.2 nM for wild type, C481S mutation BTK, respectively. WS-11 can form strong π-π interaction with PHE540 and form p-π interaction with LYS430 within the active pocket, besides the strong hydrogen bonds[1].
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WS-11 | WS-11 is a non-covalent reversible BTK inhibitor with IC50s of 3.9 nM and 2.2 nM for wild type, C481S mutation BTK, respectively. WS-11 can form strong π-π interaction with PHE540 and form p-π interaction with LYS430 within the active pocket, besides the strong hydrogen bonds. | |||||||||||||||||||||
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