2760329-44-8
2760329-44-8
Chemical Structure
IRAK1/4/pan-FLT3 Kinase-IN-2
- CAS No.: 2760329-44-8
- Formula:C20H22F3N5O
- Molecular Weight:405.42
SMILES: CC(C)OC1=CC2=NC=C(C3=C(F)C=C(F)C(N[C@H]4CNCC[C@@H]4F)=N3)N2C=C1
Biological Activity: IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent IRAK1/4 and FLT3 dual inhibitor with IC50s of 10, 0.7, and <0.5 nM. IRAK1/4/pan-FLT3 Kinase-IN-2 extends acute myeloid leukemia model mouse survival[1].
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IRAK1/4/pan-FLT3 Kinase-IN-2 | IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent IRAK1/4 and FLT3 dual inhibitor with IC50s of 10, 0.7, and <0.5 nM. IRAK1/4/pan-FLT3 Kinase-IN-2 extends acute myeloid leukemia model mouse survival. | |||||||||||||||||||||
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