2760467-77-2
Chemical Structure
10A1P16
- CAS No.: 2760467-77-2
- Formula:C38H80NO4P
- Molecular Weight:646.02
InChIKey: HBIDYGDSIHLKSU-UHFFFAOYSA-N
SMILES: O=P(OCCCCCCCCCCCCCCCC)([O-])OCC[NH+](CCCCCCCCCC)CCCCCCCCCC
Biological Activity: 10A1P16 is an ionizable phospholipid composed of a tertiary amine, a phosphate group and three hydrophobic tails. As a spleen-selective RNA delivery vector, 10A1P16 successfully transfects approximately 30% of splenic macrophages and 6% of splenic B cells in vivo. 10A1P16 can be used to prepare spleen-selective 10A1P16-MDOA lipid nanoparticles, which effectively mediate mRNA delivery and gene editing in mouse models. This delivery system retains potent spleen-targeted mRNA delivery efficacy and can be applied to ovarian cancer research[1][2][3].
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10A1P16 | 10A1P16 is an ionizable phospholipid composed of a tertiary amine, a phosphate group and three hydrophobic tails. As a spleen-selective RNA delivery vector, 10A1P16 successfully transfects approximately 30% of splenic macrophages and 6% of splenic B cells in vivo. 10A1P16 can be used to prepare spleen-selective 10A1P16-MDOA lipid nanoparticles, which effectively mediate mRNA delivery and gene editing in mouse models. This delivery system retains potent spleen-targeted mRNA delivery efficacy and can be applied to ovarian cancer research. | |||||||||||||||||||||
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References
- [1]. Liu S, et al. Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing[J]. Nature materials, 2021, 20(5): 701-710. [Content Brief]
- [2]. Song D, et al. Tuning lipid nanoparticles for RNA delivery to extrahepatic organs[J]. Advanced Materials, 2024, 36(44): 2401445. [Content Brief]
- [3]. Fu L, et al. ‘Passive’nanoparticles for organ-selective systemic delivery: design, mechanism and perspective[J]. Chemical Society Reviews, 2023, 52(21): 7579-7601. [Content Brief]
