2760515-88-4
2760515-88-4
Chemical Structure
mG2N001
- CAS No.: 2760515-88-4
- Formula:C18H19FN2O3
- Molecular Weight:330.35
InChIKey: BGZMSLRKXOWQCL-UHFFFAOYSA-N
SMILES: O=C(C1=NC2=C(C(C3=C(F)C=C(OC)C=C3)=C1)CCC(C)(C)O2)N
Biological Activity: mG2N001 is a negative allosteric modulator (NAM) (IC50: 93 nM) of the metabotropic glutamate receptor mGluR2 and binds to mGluR2 as an antagonist (Ki: 63 nM). mG2N001 is microparticle- and plasma-stable, and its radioisotope [11C]mG2N001 can be used in PET imaging. [11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images[1].
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mG2N001 | mG2N001 is a negative allosteric modulator (NAM) (IC50: 93 nM) of the metabotropic glutamate receptor mGluR2 and binds to mGluR2 as an antagonist (Ki: 63 nM). mG2N001 is microparticle- and plasma-stable, and its radioisotope [11C]mG2N001 can be used in PET imaging. [11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images. | |||||||||||||||||||||
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