2760584-90-3
Chemical Structure
CSF1R-IN-3
- CAS No.: 2760584-90-3
- Formula:C30H38N8O4
- Molecular Weight:574.67
IUPAC Name: (Z)-N-(5-((6-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrol-3-yl)-2-(4-methylpiperazin-1-yl)acetamide
InChIKey: YLKFFTVAKILRBN-STZFKDTASA-N
SMILES: O=C1NC2=CC(NC(NC3=NOC(C(C)(C)C)=C3)=O)=CC=C2/C1=C/C4=C(C)C(NC(CN5CCN(C)CC5)=O)=C(C)N4
Biological Activity: CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CSF1R-IN-3 | 98.10% | CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity. | ||||||||||||||||||||
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