2761009-43-0
Chemical Structure
CXCR4 antagonist 3
- CAS No.: 2761009-43-0
- Formula:C22H31N5
- Molecular Weight:365.52
IUPAC Name: N1-(((R)-5,6,7,8-tetrahydro-1,6-naphthyridin-7-yl)methyl)-N1-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
InChIKey: AJBIIZLEMNVANQ-CTNGQTDRSA-N
SMILES: NCCCCN([C@@H]1C2=NC=CC=C2CCC1)C[C@@H]3NCC4=C(C3)N=CC=C4
Biological Activity: CXCR4 antagonist 3 (compound 12a) is a potent antagonist of CXCR4 with an IC50 of 11 nM. CXCR4 antagonist 3 is a congener of TIQ15. CXCR4 antagonist 3 demonstrates the best overall properties including CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. CXCR4 antagonist 3 has the potential for the research of human immunodeficiency virus[1].
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CXCR4 antagonist 3 | CXCR4 antagonist 3 (compound 12a) is a potent antagonist of CXCR4 with an IC50 of 11 nM. CXCR4 antagonist 3 is a congener of TIQ15. CXCR4 antagonist 3 demonstrates the best overall properties including CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. CXCR4 antagonist 3 has the potential for the research of human immunodeficiency virus. | |||||||||||||||||||||
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