2761881-65-4
Chemical Structure
P-gp-IN-30
- CAS No.: 2761881-65-4
- Formula:C34H36N2O9
- Molecular Weight:616.66
SMILES: CCOC(C1([C@]2(C3=CC=CC=C3NC2=O)[C@H](C4=CC=CC=C4)[C@@H](C5=CC[C@@]6([H])[C@]5([H])[C@H](OC)OC=C6C(OC)=O)N1)C(OCC)=O)=O
Biological Activity: P-gp-IN-30 (Compound 13) is a P-glycoprotein (P-gp) inhibitor by targeting YB-1. P-gp-IN-30 significantly enhances sensitivity to Paclitaxel by reducing total YB-1 and nucleus YB-1 protein expression, inhibiting the expression and function of downstream P-gp, further suppressing the efflux rate of Paclitaxel. P-gp-IN-30 potently inhibits tumor growth in A549/Taxol xenografts mice model with combination of Paclitaxel (HY-B0015). P-gp-IN-30 can be used for non-small cell lung cancer (NSCLC) research[1].
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P-gp-IN-30 | P-gp-IN-30 (Compound 13) is a P-glycoprotein (P-gp) inhibitor by targeting YB-1. P-gp-IN-30 significantly enhances sensitivity to Paclitaxel by reducing total YB-1 and nucleus YB-1 protein expression, inhibiting the expression and function of downstream P-gp, further suppressing the efflux rate of Paclitaxel. P-gp-IN-30 potently inhibits tumor growth in A549/Taxol xenografts mice model with combination of Paclitaxel (HY-B0015). P-gp-IN-30 can be used for non-small cell lung cancer (NSCLC) research. | |||||||||||||||||||||
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