2762518-76-1
Chemical Structure
GDP-Fucose-Tz
Synonym(s): GDP-Fucose-Am-Tz
- CAS No.: 2762518-76-1
- Formula:C36H52N10O21P2
- Molecular Weight:1022.80
InChIKey: FDHASYQWHCLAFG-HAVGGLFBSA-N
SMILES: O=C1NC(N)=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(O[C@H]4O[C@@H](CNC(CCOCCOCCOCCOCCOC5=CC=C(C6=NN=C(C)N=N6)C=C5)=O)[C@@H](O)[C@@H](O)[C@@H]4O)(O)=O)(O)=O)[C@@H](O)[C@H]3O
Biological Activity: GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a non-natural GDP-fucose analog bearing a Tetrazine group. As a precursor, GDP-Fucose-Tz enables the synthesis of GDP-fucose-ssDNA probes via inverse electron demand Diels-Alder reaction. GDP-Fucose-Tz participates in chemoenzymatic reactions to prepare GDP-fucose-Herceptin derivatives through conjugation with TCO-Herceptin[1][2].
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GDP-Fucose-Tz | GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a non-natural GDP-fucose analog bearing a Tetrazine group. As a precursor, GDP-Fucose-Tz enables the synthesis of GDP-fucose-ssDNA probes via inverse electron demand Diels-Alder reaction. GDP-Fucose-Tz participates in chemoenzymatic reactions to prepare GDP-fucose-Herceptin derivatives through conjugation with TCO-Herceptin. | |||||||||||||||||||||
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References
- [1]. Yu W, et al. Chemoenzymatic Measurement of LacNAc in Single-Cell Multiomics Reveals It as a Cell-Surface Indicator of Glycolytic Activity of CD8+ T Cells. J Am Chem Soc. 2023;145(23):12701-12716. [Content Brief]
- [2]. Ding H, et al. Thermoelectric Nanofluidics Probing Thermal Heterogeneity inside Single Cells. J Am Chem Soc. 2023;145(41):22433-22441. [Content Brief]
