2763063-40-5
Chemical Structure
NGI-235
- CAS No.: 2763063-40-5
- Formula:C25H30N4O3S2
- Molecular Weight:498.66
IUPAC Name: 5-(N-benzyl-N-methylsulfamoyl)-2-((cyclopropylmethyl)(methyl)amino)-N-(5-ethylthiazol-2-yl)benzamide
InChIKey: YLSUNPCLEGBRJY-UHFFFAOYSA-N
SMILES: O=C(C1=CC(S(=O)(N(CC2=CC=CC=C2)C)=O)=CC=C1N(CC3CC3)C)NC4=NC=C(CC)S4
Biological Activity: NGI-235 is an STT3A-selective oligosaccharyltransferase complex OST-A inhibitor. NGI-235 preferentially inhibits OST-A catalytic activity, impairing N-glycosylation of OST-A substrates. NGI-235 causes the hypoglycosylation of both TLR4, GLUT1 and inhibits NF-κB signaling. NGI-235 can be used for the research of inflammation[1].
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NGI-235 | 99.70% | NGI-235 is an STT3A-selective oligosaccharyltransferase complex OST-A inhibitor. NGI-235 preferentially inhibits OST-A catalytic activity, impairing N-glycosylation of OST-A substrates. NGI-235 causes the hypoglycosylation of both TLR4, GLUT1 and inhibits NF-κB signaling. NGI-235 can be used for the research of inflammation. | ||||||||||||||||||||
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