2763260-36-0
Chemical Structure
NRX-103094
- CAS No.: 2763260-36-0
- Formula:C20H11Cl2F3N2O4S
- Molecular Weight:503.28
IUPAC Name: 3-(4-((2,6-dichlorophenyl)thio)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamido)benzoic acid
InChIKey: HFBGFWJURBVNFD-UHFFFAOYSA-N
SMILES: OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)=O)=C1)=O
Biological Activity: NRX-103094 is a Molecular glue and β-catenin/β-TrCP interaction enhancer, with an EC50 of 62 nM for the binding of pSer33/S37A β-catenin peptide to recombinant β-TrCP/Skp1 complex. NRX-103094 shows selectivity for Ser37 phosphorylation-deficient β-catenin, and has no effect on wild-type doubly phosphorylated β-catenin or other β-TrCP substrates. NRX-103094 can be used in research related to colorectal cancer and ovarian endometrioid adenocarcinoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NRX-103094 | 99.89% | NRX-103094 is a Molecular glue and β-catenin/β-TrCP interaction enhancer, with an EC50 of 62 nM for the binding of pSer33/S37A β-catenin peptide to recombinant β-TrCP/Skp1 complex. NRX-103094 shows selectivity for Ser37 phosphorylation-deficient β-catenin, and has no effect on wild-type doubly phosphorylated β-catenin or other β-TrCP substrates. NRX-103094 can be used in research related to colorectal cancer and ovarian endometrioid adenocarcinoma. | ||||||||||||||||||||
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References
- [1]. Wang B, et al. Emerging strategies for prospective discovery of molecular glue degraders. Current opinion in structural biology. 2024 Jun;86:102811.
- [2]. Simonetta KR, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature communications. 2019 Mar 29;10(1):1402. [Content Brief]
