2763672-36-0
2763672-36-0
Chemical Structure
YYSW001
- CAS No.: 2763672-36-0
- Formula:C18H20F5N5O
- Molecular Weight:417.38
InChIKey: CSNKKVOXYXMASY-MNOVXSKESA-N
SMILES: O[C@@H](C1=NC2=CN=C3NC=CC3=C2N1[C@@H]4CN(CC4)CCC(C(F)(F)F)(F)F)C
Biological Activity: YYSW001 is a selective and orally acrive JAK1 inhibitor with an IC50 of 6 nM and a Kd of 32.32 μM. YYSW001 blocks JAK1-dependent phosphorylation of STAT6, as well as IL-6-induced phosphorylation of STAT3. YYSW001 suppresses pro-inflammatory cytokine levels, reduces paw swelling, lowers clinical arthritis scores, alleviates joint damage and decreases bone loss. YYSW001 is applicable for the research of rheumatoid arthritis[1].
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YYSW001 | YYSW001 is a selective and orally acrive JAK1 inhibitor with an IC50 of 6 nM and a Kd of 32.32 μM. YYSW001 blocks JAK1-dependent phosphorylation of STAT6, as well as IL-6-induced phosphorylation of STAT3. YYSW001 suppresses pro-inflammatory cytokine levels, reduces paw swelling, lowers clinical arthritis scores, alleviates joint damage and decreases bone loss. YYSW001 is applicable for the research of rheumatoid arthritis. | |||||||||||||||||||||
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