2763758-01-4
Chemical Structure
Basivarsen linker
- CAS No.: 2763758-01-4
- Formula:C50H81N11O16
- Molecular Weight:1092.24
IUPAC Name: ((5aR,6S,6aS)-1-((6S,9S)-1-amino-6-((4-((carbamoyloxy)methyl)phenyl)carbamoyl)-9-isopropyl-1,8,11-trioxo-14,17,20-trioxa-2,7,10-triazadocosan-22-yl)-1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d][1,2,3]triazol-6-yl)methyl (15-amino-15-oxo-3,6,9,12-tetraoxapentadecyl)carbamate
InChIKey: BXUWIQTWHNDLIK-YXXZEEAUSA-N
SMILES: NC(CCOCCOCCOCCOCCNC(OC[C@H]1[C@]2([H])[C@@]1([H])CCC3=C(N(N=N3)CCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(N)=O)=O)=O)=O)CC2)=O)=O
Biological Activity: Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab Zeleciment (HY-P990780) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).
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Basivarsen linker | Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab Zeleciment (HY-P990780) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1). | |||||||||||||||||||||
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