2764596-06-5
2764596-06-5
Chemical Structure
P-gp/BCRP-IN-1
- CAS No.: 2764596-06-5
- Formula:C27H25ClN4O3
- Molecular Weight:488.97
IUPAC Name: 3-(4-chlorophenyl)-N-(4-(2-morpholinoethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide
InChIKey: XFURMSAITSZFAY-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C(C2=CC=CC=C21)=O)C3=CC=C(C=C3)Cl)NC4=CC=C(C=C4)CCN5CCOCC5
Biological Activity: P-gp/BCRP-IN-1 (compound 19) is a potential, relatively safe, orally active and efficient efflux transporter (P-gp and BCRP) inhibitor. P-gp/BCRP-IN-1 exerts resistance reversal by inhibiting the efflux function of P-gp and BCRP. P-gp/BCRP-IN-1 can overcome the resistance and improve the oral bioavailability of PTX (Paclitaxel)[1].
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P-gp/BCRP-IN-1 | P-gp/BCRP-IN-1 (compound 19) is a potential, relatively safe, orally active and efficient efflux transporter (P-gp and BCRP) inhibitor. P-gp/BCRP-IN-1 exerts resistance reversal by inhibiting the efflux function of P-gp and BCRP. P-gp/BCRP-IN-1 can overcome the resistance and improve the oral bioavailability of PTX (Paclitaxel). | |||||||||||||||||||||
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