2764772-88-3
2764772-88-3
Chemical Structure
EGFR-IN-46
- CAS No.: 2764772-88-3
- Formula:C27H32F3N3O3
- Molecular Weight:503.56
IUPAC Name: N-(3-((6,7-dimethoxy-2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)oxy)propyl)-1-methylpiperidin-4-amine
InChIKey: GTFSJMZEXMPUJA-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(N=C(C=C2OCCCNC3CCN(CC3)C)C4=CC=C(C=C4)C(F)(F)F)=C1)OC
Biological Activity: EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1].
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EGFR-IN-46 | EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis. | |||||||||||||||||||||
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