2764877-61-2
2764877-61-2
Chemical Structure
SLF80821178
- CAS No.: 2764877-61-2
- Formula:C21H35N3O
- Molecular Weight:345.52
InChIKey: ZLCZPMKDZPCCEV-UHFFFAOYSA-N
SMILES: O=C(N1CCNCC1)NC2=CC=C(CCCCCCCCCC)C=C2
Biological Activity: SLF80821178 is an orally active Spns2 inhibitor that inhibits S1P release with an IC50 of 51 nM in HeLa cells. SLF80821178 blocks Spns2-mediated S1P transport/release, induces lymphopenia, and reduces circulating B cell, NK cell, and T cell populations. SLF80821178 can be used for research on multiple sclerosis[1][2][3].
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SLF80821178 | 99.70% | SLF80821178 is an orally active Spns2 inhibitor that inhibits S1P release with an IC50 of 51 nM in HeLa cells. SLF80821178 blocks Spns2-mediated S1P transport/release, induces lymphopenia, and reduces circulating B cell, NK cell, and T cell populations. SLF80821178 can be used for research on multiple sclerosis. | ||||||||||||||||||||
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References
- [1]. Foster DJ, et al. Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of medicinal chemistry. 2024 Jul 11;67(13):11273-11295. [Content Brief]
- [2]. Kharel Y, et al. Assessment of Spinster homologue 2 (Spns2)-dependent transport of sphingosine-1-phosphate as a therapeutic target. British journal of pharmacology. 2025 May;182(9):2014-2030.
- [3]. Kharel Y, et al. Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target. bioRxiv. 2024 Mar 29:2024-03.
