2764891-88-3
2764891-88-3
Chemical Structure
RET-IN-11
- CAS No.: 2764891-88-3
- Formula:C27H30FN9O
- Molecular Weight:515.59
IUPAC Name: N-(3-fluorophenyl)-2-(4-((4-((3-methyl-1H-pyrazol-5-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)phenyl)acetamide
InChIKey: QJOKMKBZEMLHIM-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(F)=C1)CC2=CC=C(NC3=NC(N4CCN(C)CC4)=CC(NC5=CC(C)=NN5)=N3)C=C2
Biological Activity: RET-IN-11 is a potent and selective RET inhibitor with IC50s of 6.20 nM, 18.68 nM for RET and RETV804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis[1].
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RET-IN-11 | RET-IN-11 is a potent and selective RET inhibitor with IC50s of 6.20 nM, 18.68 nM for RET and RETV804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis. | |||||||||||||||||||||
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