2765008-88-4
2765008-88-4
Chemical Structure
Atg4B-IN-2
- CAS No.: 2765008-88-4
- Formula:C21H30O3
- Molecular Weight:330.46
IUPAC Name: 2,5-bis(4-(10H-phenoxazin-10-yl)phenyl)-1,3,4-thiadiazole
InChIKey: XEPLKXYXNJMMCI-WUKNDPDISA-N
SMILES: O=C(C1=CC=C(C=C1)CCCCCCCCCCC)/C=C/C(O)=O
Biological Activity: Atg4B-IN-2 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition[1].
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Atg4B-IN-2 | 98.03% | Atg4B-IN-2 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition. | ||||||||||||||||||||
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