2765058-89-5
2765058-89-5
Chemical Structure
10-SLF
- CAS No.: 2765058-89-5
- Formula:C59H76Cl2N4O13
- Molecular Weight:1120.16
InChIKey: XVRCAVJOLKVISC-MABACLQESA-N
SMILES: O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@H](CCC2=CC(OC)=C(C=C2)OC)C3=CC=CC(OCC(NCCCOCCOCCOCCCN(C(CCl)=O)C(C4=CC=C(C=C4)Cl)C(NCC5=CC=CC=C5)=O)=O)=C3
Biological Activity: 10-SLF is an FKBP12 PROTAC degrader. 10-SLF covalently interacts with the cysteine residue of FBXW7R465C, forms a ternary complex with FKBP12, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF can be used for the research of pancreatic cancer[1].
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10-SLF | 10-SLF is an FKBP12 PROTAC degrader. 10-SLF covalently interacts with the cysteine residue of FBXW7R465C, forms a ternary complex with FKBP12, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF can be used for the research of pancreatic cancer. | |||||||||||||||||||||
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