2765560-03-8
2765560-03-8
Chemical Structure
EGFR-IN-45
- CAS No.: 2765560-03-8
- Formula:C28H23N7O
- Molecular Weight:473.53
IUPAC Name: (E)-4-((4-amino-2-phenylpyrimido[5,4-c]quinolin-5(6H)-ylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
InChIKey: MDSMFLZNYFGNHZ-UHFFFAOYSA-N
SMILES: NC1=NC(C2=CC=CC=C2)=NC3=C1C(NC4=CC=CC=C43)=NC5=C(C)N(C)N(C6=CC=CC=C6)C5=O
Biological Activity: EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 µM and 1.6 µM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis[1].
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EGFR-IN-45 | EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 µM and 1.6 µM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis. | |||||||||||||||||||||
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