2766185-78-6
2766185-78-6
Chemical Structure
Mpro/PLpro-IN-1
- CAS No.: 2766185-78-6
- Formula:C25H27ClN4O3
- Molecular Weight:466.96
IUPAC Name: (S)-N-((S)-1-(benzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-(2-chloroacetamido)pent-4-enamide
InChIKey: DMHYAQLYAFULCU-VXKWHMMOSA-N
SMILES: C=CC[C@H](NC(CCl)=O)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(NCC3=CC=CC=C3)=O)=O
Biological Activity: Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of Mpro/PLpro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus Mpro (IC50 = 1.72 μM) and submicromolar potency versus PLpro (IC50 = 0.67 μM)[1].
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Mpro/PLpro-IN-1 | Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of Mpro/PLpro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus Mpro (IC50 = 1.72 μM) and submicromolar potency versus PLpro (IC50 = 0.67 μM). | |||||||||||||||||||||
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