2766385-23-1
Chemical Structure
Petrelintide
Synonym(s): ZP8396
- CAS No.: 2766385-23-1
- Formula:C185H305N49O61
- Molecular Weight:4191.69
SMILES: OC(CCCCCCCCCCCCCCCCCCC(N[C@H](C(O)=O)CCC(N[C@H](C(N[C@H]1CC(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N(CC(N[C@H](C(N([C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N2C[C@@H](C[C@H]2C(N)=O)O)=O)[C@H](O)C)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)CCC(O)=O)=O)[C@H](O)C)=O)CO)=O)CO)=O)CC(C)C)=O)[C@H](CC)C)C)=O)C)=O)C)=O)CC3=CC=CC=C3)=O)CO)=O)CO)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC(C)C)=O)CC4=CC=CC=C4)=O)CCCC(O)=O)=O)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)[C@H](O)C)=O)C)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC1=O)=O)=O)C)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)=O
Biological Activity: Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Petrelintide | 99.49% | Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research. | ||||||||||||||||||||
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References
- [1]. Zong L, et al. Discovery of BGM1812, a Novel Dual Amylin and Calcitonin Receptor Agonist for Obesity Treatment. J Med Chem. 2025 Jul 24;68(14):14907-14918. [Content Brief]
- [2]. BILL V, et al. 1661-P: Petrelintide (ZP8396) Selectively Reduces Intake of High-Fat Diet in DIO Rats. Diabetes 14 June 2024; 73 (Supplement_1): 1661-P.
- [3]. BILL V, et al. 1662-P: Petrelintide (ZP8396) Significantly Reduces Fat Mass while Preserving Lean Mass in DIO Rats. Diabetes 14 June 2024; 73 (Supplement_1): 1662-P.
- [4]. JON G, et al. 1668-P: Novel Once-Weekly Amylin Analog Petrelintide (ZP8396) Is Well Tolerated with Improved GI Tolerability after Multiple Dosing, Diabetes, 2024;73(Supplement_1):1668-P
