2766385-92-4
2766385-92-4
Chemical Structure
TMX-4113
- CAS No.: 2766385-92-4
- Formula:C12H12N4O2S2
- Molecular Weight:308.38
IUPAC Name: 3-(4-(4-(methylthio)thiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione
InChIKey: YIIUEHDPOPLUBR-UHFFFAOYSA-N
SMILES: O=C(C(N1N=NC(C2=CSC=C2SC)=C1)CC3)NC3=O
Biological Activity: TMX-4113 is a FPFT-2216 (HY-145319) (Molecular glue) analog and degrader of PDE6D and CK1α. TMX-4113 does not inhibit the growth of KRASG12C-dependent cancer cells. TMX-4113 can be used in the research of multiple myeloma, pancreatic ductal adenocarcinoma, non-small cell lung cancer and gastric adenocarcinoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TMX-4113 | 99.08% | TMX-4113 is a FPFT-2216 (HY-145319) (Molecular glue) analog and degrader of PDE6D and CK1α. TMX-4113 does not inhibit the growth of KRASG12C-dependent cancer cells. TMX-4113 can be used in the research of multiple myeloma, pancreatic ductal adenocarcinoma, non-small cell lung cancer and gastric adenocarcinoma. | ||||||||||||||||||||
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References
- [1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. Journal of medicinal chemistry. 2022 Jan 13;65(1):747-756. [Content Brief]
- [2]. Li F, et al. Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein-Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases. International journal of molecular sciences. 2022 Jun 01;23(11):6206.
