2766407-55-8
2766407-55-8
Chemical Structure
ATR-IN-18
- CAS No.: 2766407-55-8
- Formula:C19H22F3N7O5S
- Molecular Weight:517.48
IUPAC Name: (R)-3-methyl-4-(1-(methylsulfonyl)-6-(1H-pyrazol-3-yl)-1,2,3,6-tetrahydropyrazolo[3,4-b]pyrrolo[2,3-d]pyridin-4-yl)morpholine 2,2,2-trifluoroacetate
InChIKey: JJRBAXQOFLQKDM-RFVHGSKJSA-N
SMILES: OC(C(F)(F)F)=O.CS(=O)(N1C2=C(CC1)C(N3[C@@H](COCC3)C)=NC4=C2C=NN4C5=NNC=C5)=O
Biological Activity: ATR-IN-18 (compound 2) is an orally active and potent ATR kinase inhibitor, with an IC50 of 0.69 nM. ATR-IN-18 shows antiproliferative activity in LoVo cells, with an IC50 of 37.34 nM. ATR-IN-18 has anti-tumor activity[1].
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ATR-IN-18 | ATR-IN-18 (compound 2) is an orally active and potent ATR kinase inhibitor, with an IC50 of 0.69 nM. ATR-IN-18 shows antiproliferative activity in LoVo cells, with an IC50 of 37.34 nM. ATR-IN-18 has anti-tumor activity. | |||||||||||||||||||||
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