2766739-35-7
Chemical Structure
RAGE/SERT-IN-1
- CAS No.: 2766739-35-7
- Formula:C38H41ClN4OS
- Molecular Weight:637.28
IUPAC Name: 3-(4-(4-(5-butyl-4-(4-(4-chlorophenoxy)phenyl)thiazol-2-yl)piperidin-1-yl)butyl)-1-methyl-1H-indole-5-carbonitrile
InChIKey: SYSZRZAQHLUSDF-UHFFFAOYSA-N
SMILES: CCCCC1=C(N=C(S1)C2CCN(CC2)CCCCC3=CN(C4=C3C=C(C=C4)C#N)C)C5=CC=C(C=C5)OC6=CC=C(C=C6)Cl
Biological Activity: RAGE/SERT-IN-1 is a potent and orally active advanced glycation end products (RAGE) and serotonin transporter (SERT) inhibitor with IC50s of 8.26 μM and 31.09 nM, respectively. RAGE/SERT-IN-1 exhibits significant neuroprotective effect against Aβ25-35-induced neuronal damage and alleviates depressive behavior of mice. RAGE/SERT-IN-1 can be used for researching the comorbidity of Alzheimer's disease and depression[1].
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RAGE/SERT-IN-1 | RAGE/SERT-IN-1 is a potent and orally active advanced glycation end products (RAGE) and serotonin transporter (SERT) inhibitor with IC50s of 8.26 μM and 31.09 nM, respectively. RAGE/SERT-IN-1 exhibits significant neuroprotective effect against Aβ25-35-induced neuronal damage and alleviates depressive behavior of mice. RAGE/SERT-IN-1 can be used for researching the comorbidity of Alzheimer's disease and depression. | |||||||||||||||||||||
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