2767424-13-3
Chemical Structure
PD-L1-IN-1
- CAS No.: 2767424-13-3
- Formula:C21H23N5O2
- Molecular Weight:377.44
IUPAC Name: N-(2-((4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)-1,3,5-triazin-2-yl)amino)ethyl)acetamide
InChIKey: LGWZTWZGNYPECF-UHFFFAOYSA-N
SMILES: CC(NCCNC1=NC(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)=NC=N1)=O
Biological Activity: PD-L1-IN-1 (Compound 10) is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly exhibits low cytotoxicity in healthy cells[1].
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PD-L1-IN-1 | 98.37% | PD-L1-IN-1 (Compound 10) is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly exhibits low cytotoxicity in healthy cells. | ||||||||||||||||||||
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