2767633-04-3
Chemical Structure
SOS1-IN-21
- CAS No.: 2767633-04-3
- Formula:C25H30F3N3O4
- Molecular Weight:493.52
IUPAC Name: (R)-1,1-difluoro-1-(2-fluoro-3-(1-((7-methoxy-6-(2-methoxyethoxy)-2-methylquinazolin-4-yl)amino)ethyl)phenyl)-2-methylpropan-2-ol
InChIKey: IXISHTPGMZTYHX-CQSZACIVSA-N
SMILES: CC(O)(C)C(F)(F)C1=CC=CC([C@H](NC2=C3C=C(OCCOC)C(OC)=CC3=NC(C)=N2)C)=C1F
Biological Activity: SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer[1].
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SOS1-IN-21 | SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer. | |||||||||||||||||||||
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