2768005-77-0
2768005-77-0
Chemical Structure
PI3K-IN-29
- CAS No.: 2768005-77-0
- Formula:C27H22ClN7O3S
- Molecular Weight:560.03
IUPAC Name: N-(2-chloro-5-(4-(2-morpholinopyrimidin-5-yl)cinnolin-6-yl)pyridin-3-yl)benzenesulfonamide
InChIKey: JDQJRYKTFFQLMZ-UHFFFAOYSA-N
SMILES: O=S(NC1=CC(C2=CC=C3N=NC=C(C3=C2)C4=CN=C(N=C4)N5CCOCC5)=CN=C1Cl)(C6=CC=CC=C6)=O
Biological Activity: PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].
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PI3K-IN-29 | PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K. | |||||||||||||||||||||
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