2768427-54-7
2768427-54-7
Chemical Structure
STAT3-IN-20
- CAS No.: 2768427-54-7
- Formula:C30H27F4N7S
- Molecular Weight:593.64
InChIKey: OOARMSSXPHSBDL-UHFFFAOYSA-N
SMILES: FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1
Biological Activity: STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis[1].
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STAT3-IN-20 | 99.83% | STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis. | ||||||||||||||||||||
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