2768485-08-9
Chemical Structure
Tubulin polymerization-IN-8
- CAS No.: 2768485-08-9
- Formula:C21H24N4O4S
- Molecular Weight:428.50
IUPAC Name: 2-((4-amino-5-(3,4,5-trimethoxybenzyl)-4H-1,2,4-triazol-3-yl)thio)-1-(p-tolyl)ethan-1-one
InChIKey: FWXJSVHACSBPBA-UHFFFAOYSA-N
SMILES: COC1=CC(CC2=NN=C(N2N)SCC(C3=CC=C(C=C3)C)=O)=CC(OC)=C1OC
Biological Activity: Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-8 concentration-dependently causes cell cycle arrest at the G2/M phase in HCT116 tumor cells, and displays a significant inhibition of tubulin polymerization with an IC50 value of 12.7 μM. Tubulin polymerization-IN-8 has the potential for the research of cancer diseases[ 1].
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Tubulin polymerization-IN-8 | Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-8 concentration-dependently causes cell cycle arrest at the G2/M phase in HCT116 tumor cells, and displays a significant inhibition of tubulin polymerization with an IC50 value of 12.7 μM. Tubulin polymerization-IN-8 has the potential for the research of cancer diseases[ 1]. | |||||||||||||||||||||
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