2768650-56-0
2768650-56-0
Chemical Structure
NLRP3-IN-8
- CAS No.: 2768650-56-0
- Formula:C23H20N2O6
- Molecular Weight:420.41
IUPAC Name: N-(4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)phenyl)furan-2-carboxamide
InChIKey: HOPNWVAJWVCASY-CQYWEGEGSA-N
SMILES: COC1=CC(OC)=C(C(/C=C/C2=CC=C(C=C2)NC(C3=CC=CO3)=O)=C1)/C=C/[N+]([O-])=O
Biological Activity: NLRP3-IN-8 (compound 27) is an orally active, directly binding NLRP3 inflammasome inhibitor with an IC50 value of 1.23 μM against IL-1 β. NLRP3-IN-8 has good metabolic stability to liver microsomes (t1/2 = 138.63 min), and has almost no toxicity (against L02: IC50 > 100 μM)[1].
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NLRP3-IN-8 | NLRP3-IN-8 (compound 27) is an orally active, directly binding NLRP3 inflammasome inhibitor with an IC50 value of 1.23 μM against IL-1 β. NLRP3-IN-8 has good metabolic stability to liver microsomes (t1/2 = 138.63 min), and has almost no toxicity (against L02: IC50 > 100 μM). | |||||||||||||||||||||
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