2769085-03-0
2769085-03-0
Chemical Structure
TLR7/8 antagonist 2
- CAS No.: 2769085-03-0
- Formula:C22H26FN5
- Molecular Weight:379.47
IUPAC Name: 5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-N-((3S,4S)-3-fluoropiperidin-4-yl)-1H-indazol-3-amine
InChIKey: JUSJRQVEHUHMRQ-PMACEKPBSA-N
SMILES: CC1=CC(C2=C(C=C3C(NN=C3N[C@H]4CCNC[C@@H]4F)=C2)C5CC5)=CC(C)=N1
Biological Activity: TLR7/8 antagonist 2 (Compound 15) is a potent and orally active agonist of TLR7/8 with IC50s of 4.9 and 0.6 nM, respectively. Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as lupus erythematosus. TLR7/8 antagonist 2 has the potential for the research of autoimmune diseases[1].
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TLR7/8 antagonist 2 | 99.68% | TLR7/8 antagonist 2 (Compound 15) is a potent and orally active agonist of TLR7/8 with IC50s of 4.9 and 0.6 nM, respectively. Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as lupus erythematosus. TLR7/8 antagonist 2 has the potential for the research of autoimmune diseases. | ||||||||||||||||||||
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