2769753-18-4
Chemical Structure
SB1-G-187
- CAS No.: 2769753-18-4
- Formula:C52H54F3N9O10
- Molecular Weight:1022.03
IUPAC Name: N-(4-((4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2-oxo-6,9,12-trioxa-3-azapentadecan-15-yl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide
InChIKey: HKRYQLKHNCVSRZ-UHFFFAOYSA-N
SMILES: O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3OCC(NCCOCCOCCOCCCN4CCN(CC5=C(C(F)(F)F)C=C(NC(C6=CC(C#CC7=CN=C8N7N=CC=C8)=C(C)C=C6)=O)C=C5)CC4)=O)=O
Biological Activity: SB1-G-187 is a multi-target kinase PROTAC degrader with activity against various kinases including GCK, YES1, IRAK1 and LYN. SB1-G-187 induces degradation of target kinases via a p97-dependent pathway, and forms ternary complexes with CRBN and specific functional kinases. SB1-G-187 can be used in tumor-related research[1].
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SB1-G-187 | 98.70% | SB1-G-187 is a multi-target kinase PROTAC degrader with activity against various kinases including GCK, YES1, IRAK1 and LYN. SB1-G-187 induces degradation of target kinases via a p97-dependent pathway, and forms ternary complexes with CRBN and specific functional kinases. SB1-G-187 can be used in tumor-related research. | ||||||||||||||||||||
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