2770688-04-3
![[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p11075.gif "[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) Chemical Structure")
Chemical Structure
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)
- CAS No.: 2770688-04-3
- Formula:C39H65N9O10
- Molecular Weight:819.99
InChIKey: QJEJIFWFGXBTDI-HLYNNXGTSA-N
SMILES: N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H](C(NCC(N([C@@H](CC(C)C)C(N[C@@H](CCCC)C(N)=O)=O)C)=O)=O)C(C)C)=O)=O)CCCCN)=O
Biological Activity: [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research[1].
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[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) | [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research. | |||||||||||||||||||||
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