2771069-76-0
2771069-76-0
Chemical Structure
GNE7599
- CAS No.: 2771069-76-0
- Formula:C31H40N6O3S
- Molecular Weight:576.75
InChIKey: IAVGSVXQQSNQFO-PWKYGKGFSA-N
SMILES: O=C([C@@H](N1N=NC(C2CC2)=C1)C(C)(C)C)N3C[C@H](O)C[C@H]3C(N[C@H]4CCCCC5=C4C=CC(C6=C(C)N=CS6)=C5)=O
Biological Activity: GNE7599 is a high-affinity VHL ligand with a Kd value of 540 pM, which binds to the VHL substrate receptor of the CRL2VHL E3 ligase. GNE7599 is cell-permeable and exhibits moderate stability in liver microsomes and hepatocytes. GNE7599 can be used in cancer-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GNE7599 | 99.19% | GNE7599 is a high-affinity VHL ligand with a Kd value of 540 pM, which binds to the VHL substrate receptor of the CRL2VHL E3 ligase. GNE7599 is cell-permeable and exhibits moderate stability in liver microsomes and hepatocytes. GNE7599 can be used in cancer-related research. | ||||||||||||||||||||
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References
- [1]. Wu H, et al. Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability. Journal of medicinal chemistry. 2024 Jun 13;67(11):8585-8608. [Content Brief]
- [2]. Urbina A, et al. A patent review of von Hippel-Lindau (VHL)-recruiting chemical matter: E3 ligase ligands for PROTACs and targeted protein degradation (2019–present). Expert Opinion on Therapeutic Patents. 2025 Mar 4;35(3):197-238.
