2771965-57-0
Chemical Structure
T-Type calcium channel inhibitor 2
- CAS No.: 2771965-57-0
- Formula:C36H39FN4OS
- Molecular Weight:594.78
IUPAC Name: 2-(3-([1,1'-biphenyl]-4-yl)-2-((5-(dimethylamino)pentyl)thio)-3,4-dihydroquinazolin-4-yl)-N-(4-fluorobenzyl)acetamide
InChIKey: DOCPLAPSOWUOSM-UHFFFAOYSA-N
SMILES: CN(CCCCCSC1=NC2=CC=CC=C2C(N1C3=CC=C(C=C3)C4=CC=CC=C4)CC(NCC5=CC=C(C=C5)F)=O)C
Biological Activity: T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively[1].
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T-Type calcium channel inhibitor 2 | T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively. | |||||||||||||||||||||
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