27724-96-5
27724-96-5
Chemical Structure
Cetraxate hydrochloride
Synonym(s): DV-1006
- CAS No.: 27724-96-5
- Formula:C17H24ClNO4
- Molecular Weight:341.83
IUPAC Name: 3-(4-(((1r,4r)-4-(aminomethyl)cyclohexane-1-carbonyl)oxy)phenyl)propanoic acid hydrochloride
InChIKey: USROQQUKEBHOFF-SKKCDYJJSA-N
SMILES: OC(CCC(C=C1)=CC=C1OC([C@H]2CC[C@@H](CC2)CN)=O)=O.Cl
Biological Activity: Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research[1]. Cetraxate hydrochloride is a potent acrosomal proteinase acrosin inhibitor with a Ki and an IC50 of 0.94 μM and 3.3 μM, respectively[2].
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Cetraxate hydrochloride | 99.37% | Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research. Cetraxate hydrochloride is a potent acrosomal proteinase acrosin inhibitor with a Ki and an IC50 of 0.94 μM and 3.3 μM, respectively. | ||||||||||||||||||||
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References
- [1]. Fumihiko Katagiri, et al. Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma. J Pharm Pharmacol. 2004 Apr;56(4):557-61. [Content Brief]
- [2]. H Sumi, et al. Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006). Experientia. 1980 Sep 15;36(9):1103-4. [Content Brief]
