2772910-13-9
2772910-13-9
Chemical Structure
PF-3837
- CAS No.: 2772910-13-9
- Formula:C21H26N8O2
- Molecular Weight:422.48
InChIKey: JCVATYGNKPJBLI-UHFFFAOYSA-N
SMILES: N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC(C)(CO)C)=C12
Biological Activity: PF-3837 is an Mps1 kinase inhibitor with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. PF-3837 interferes with the cell cycle checkpoint by inhibiting Mps1 catalytic activity, reducing genomic stability, thereby inducing cancer cell apoptosis (Apoptosis). PF-3837 can be used in research on breast cancer[1].
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PF-3837 | PF-3837 is an Mps1 kinase inhibitor with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. PF-3837 interferes with the cell cycle checkpoint by inhibiting Mps1 catalytic activity, reducing genomic stability, thereby inducing cancer cell apoptosis (Apoptosis). PF-3837 can be used in research on breast cancer. | |||||||||||||||||||||
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