27750-13-6
Chemical Structure
(-)-Hydroxycitric acid lactone
Synonym(s): Garcinia lactone
- CAS No.: 27750-13-6
- Formula:C6H6O7
- Molecular Weight:190.11
IUPAC Name: (2S,3S)-3-hydroxy-5-oxotetrahydrofuran-2,3-dicarboxylic acid
InChIKey: PFHZIWAVXDSFTB-CVYQJGLWSA-N
SMILES: O[C@](CC(O1)=O)(C(O)=O)[C@H]1C(O)=O
Biological Activity: (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].
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(-)-Hydroxycitric acid lactone | 99.92% | (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis. | ||||||||||||||||||||
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(-)-Hydroxycitric acid lactone (Standard) | ≥98% | (-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis. | ||||||||||||||||||||
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References
- [1]. Jena BS, et al. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric Food Chem. 2002 Jan 2;50(1):10-22. [Content Brief]
- [2]. Han J, et al. (-)-Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related geneexpression in broiler chickens. Lipids Health Dis. 2016 Feb 24;15:37. [Content Brief]
